The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones.

摘要: The sensitivity of the protein-folding environment to chaperone disruption can be highly tissue-specific. Yet, organization system across physiological human tissues has received little attention. Through computational analyses large-scale tissue transcriptomes, we unveil that is composed core elements are uniformly expressed tissues, and variable differentially fit with tissue-specific requirements. We demonstrate via a proteomic analysis muscle-specific signature functional conserved. Core chaperones significantly more abundant important for cell survival than chaperones. Together chaperones, they form networks. Analysis organ development aging brain transcriptomes reveals these networks established in decline age. In this work, expand known de novo versus stress-inducible eukaryotic into layered core-variable architecture multi-cellular organisms. Tissue-specific differences protein folding capacities poorly understood. Here, authors show consists ubiquitous perturbation which leads phenotypes.