Parkinson's disease: A genetic perspective

摘要: Parkinson's disease (PD) is a common neurodegenerative disorder in the aging population, affecting more than 1% over age of 65 years. Certain rare forms are monogenic, representing 5-10% PD patients, but there increasing evidence that multiple genetic risk factors important also for PD. To date, 13 loci, PARK1-13, have been suggested such as autosomal dominant and recessive At six these genes identified reported by several groups to carry mutations linked affected family members. Genes which familial shown be candidate idiopathic PD, those same may other merely increase risk. Four PARK genes, SNCA at PARK1, UCH-L1 PARK5, PINK1 PARK6 LRRK2 PARK8, implicated sporadic There indeed combine different ways or decrease risk, need order begin unwinding causative pathways leading In this review, we present molecular genetics understood today, help explain neurodegeneration.