Neighborhood characteristics influence DNA methylation of genes involved in stress response and inflammation: The Multi-Ethnic Study of Atherosclerosis.

摘要: Living in a disadvantaged neighborhood is associated with poor health outcomes even after accounting for individual-level socioeconomic factors. The chronic stress of unfavorable conditions may lead to dysregulation the reactivity and inflammatory pathways, potentially mediated through epigenetic mechanisms such as DNA methylation. We used multi-level models examine relationship between 2 methylation levels 18 genes related inflammation purified monocytes from 1,226 participants Multi-Ethnic Study Atherosclerosis (MESA), population-based sample US adults. Neighborhood disadvantage, summary 16 census-based metrics, was [False discovery rate (FDR) q-value ≤ 0.1] out 7 stress-related evaluated (CRF, SLC6A4) 11 inflammation-related (F8, TLR1). social environment, measure aesthetic quality, safety, cohesion, 4 (AVP, BDNF, FKBP5, (CCL1, CD1D, F8, KLRG1, NLRP12, SLAMF7, High disadvantage worse environment were primarily increased In 5 significant associations (FKBP5, NLRP12), gene expression at least one transcript. These results demonstrate that multiple dimensions context influence subsequent stress- genes, individual Further elucidating molecular underlying these relationships will be important understanding etiology disparities.