Postradiation Histiocytic Sarcoma in the Setting of Muir-Torre Syndrome

摘要: Hereditary nonpolyposis colorectal carcinoma (HNPCC) is an autosomal dominant genetic disorder characterized by a predisposition towards and other extracolonic neoplasms. Histiocytic sarcoma (HS) very rare hematologic neoplasm malignant proliferation of cells with histiocytic differentiation. We present the case 62-year-old male previous diagnosis MTS who presented metastatic adenocarcinoma, bilateral papillary renal cell carcinoma, new squamous scalp, treated resection adjuvant radiation therapy. After reconstructive surgery for his scalp resection, patient developed persistent nonhealing skin defect. A punch biopsy this defect subsequent immunohistochemistry revealed neoplastic restricted to epidermis underlying dermis. The cutaneous was then rendered. exceptionally malignancy. Consequently, there no universally agreed upon management protocol admitted hospice palliative radiation. This demonstrates need awareness risk secondary malignancies in cancer patients order facilitate early surgical intervention optimal treatment.