Biological Barriers for Drug Targeting

作者: Vladimir R. Muzykantov

DOI: 10.1007/978-1-4757-4627-3_2

关键词:

摘要: Applications of large, complex carriers that deliver powerful, specific and sensitive agents (cytokines, toxins, enzymes genetic materials) face formidable challenges. Drug targeting strategies have to traverse diverse barriers: biological (e.g., associated with drug delivery, subcellular addressing a drug, metabolization carriers, etc), technological production, dosing, shelf-life drug-carrier complexes) socioeconomical price, practical utility public accessibility strategy).

参考文章(21)
Mark J. Walport, Complement. First of two parts. The New England Journal of Medicine. ,vol. 344, pp. 1058- 1066 ,(2001) , 10.1056/NEJM200104053441406
A Abuchowski, J R McCoy, N C Palczuk, T van Es, F F Davis, Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase. Journal of Biological Chemistry. ,vol. 252, pp. 3582- 3586 ,(1977) , 10.1016/S0021-9258(17)40292-4
Byeongmoon Jeong, You Han Bae, Doo Sung Lee, Sung Wan Kim, Biodegradable block copolymers as injectable drug-delivery systems Nature. ,vol. 388, pp. 860- 862 ,(1997) , 10.1038/42218
Stephen M. Vogel, Richard D. Minshall, Milena Pilipović, Chinnaswamy Tiruppathi, Asrar B. Malik, Albumin uptake and transcytosis in endothelial cells in vivo induced by albumin-binding protein. American Journal of Physiology-lung Cellular and Molecular Physiology. ,vol. 281, ,(2001) , 10.1152/AJPLUNG.2001.281.6.L1512
Janos Szebeni, The interaction of liposomes with the complement system. Critical Reviews in Therapeutic Drug Carrier Systems. ,vol. 15, pp. 57- 88 ,(1998) , 10.1615/CRITREVTHERDRUGCARRIERSYST.V15.I1.20
J. Rosenecker, W. Zhang, K. Hong, J. Lausier, P. Geppetti, S. Yoshihara, D. Papahadjopoulos, J. A. Nadel, Increased Liposome Extravasation in Selected Tissues: Effect of Substance P Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 7236- 7241 ,(1996) , 10.1073/PNAS.93.14.7236
J. Juraszek, A. Fnidiki, J. Teillet, Structural and magnetic transformations of annealed Tb/Fe multilayers Journal of Applied Physics. ,vol. 84, pp. 379- 385 ,(1998) , 10.1063/1.368039
M. D. Scott, K. L. Murad, F. Koumpouras, M. Talbot, J. W. Eaton, Chemical camouflage of antigenic determinants: Stealth erythrocytes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 7566- 7571 ,(1997) , 10.1073/PNAS.94.14.7566
M Narita, G Bu, J Herz, A L Schwartz, Two receptor systems are involved in the plasma clearance of tissue-type plasminogen activator (t-PA) in vivo. Journal of Clinical Investigation. ,vol. 96, pp. 1164- 1168 ,(1995) , 10.1172/JCI118105