Reversal of Capillary Stasis and Prevention of Necrosis in Burns

摘要: It has been suggested that the ultimate depth of burn necrosis might be minimized by prevention or reversal progressive capillary stasis which occurs in early postburn hours. To study role wound dehydration determining depth, 5% body surface area, 75 C, 10 second burns (in zone included full thickness skin) were inflicted on backs guinea pigs and subsequent mechanical trauma was prevented. At various times postburn, water content, (and after India ink perfusion) histological structure studied following groups: 1) blister intact; 2) removed; 3) replaced several different types dressing. Reversal least full-thickness undressed wounds with removed. complete absent fresh split-thickness porcine skin correlated dehydration. Similar, though less complete, occurred intact sialastic film. Other dressings associated deep gross infection. These other data suggest stasis, may reversed avoided appropriate Clinical correlations are suggested.