Expression and activity of the POU transcription factor SCIP.
作者： E. Monuki , R Kuhn , G Weinmaster , B. Trapp , G Lemke
关键词:
摘要: POU proteins have been shown to transcriptionally active cell-specific genes and participate in the determination of cell fate. It is therefore thought that these function development through stable activation define specific developmental pathways. Evidence provided here for an alternative mode action. The primary structure SCIP, a protein expressed by developing Schwann cells peripheral nervous system, was deduced SCIP activity studied. Both normal response nerve transection, expression transiently activated only during period rapid division separates premyelinating myelinating phases differentiation. In cotransfection assays, acted as transcriptional repressor myelin-specific genes.
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