Synthesis of a monophosphoryl derivative of Escherichia coli lipid A and its efficient coupling to a tumor-associated carbohydrate antigen.
作者： Shouchu Tang , Qianli Wang , Zhongwu Guo
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摘要: Monophosphoryl lipid A is a safe and potent immunostimulant vaccine adjuvant, which potentially useful for the development of effective carbohydrate-based conjugate vaccines. This paper presents convergent efficient synthesis monophosphoryl derivative E. coli that has an alkyne functionality at reducing end, suitable coupling with various molecules. The this to N-modified analogue tumor-associated antigen GM3 through click chemistry also presented.
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