Monophosphoryl Lipid A and Synthetic Lipid A Mimetics As TLR4-Based Adjuvants and Immunomodulators
作者： Jory Baldridge , Kent Myers , David Johnson , David Persing , Christopher Cluff
DOI: 10.1007/978-1-59259-970-7_12
关键词:
摘要: MPL adjuvant, a monophosphoryl lipid A (MLA) derivative of the lipopolysaccharide (LPS) from Salmonella minnesota R595, and RC-529, synthetic mimetic, are promising adjuvant candidates for number human vaccines have been shown to be safe, well-tolerated, effectively enhance immune responses co-administered vaccine antigens. Preliminary evidence suggests that, like LPS, MLA RC-529 activate cells via pattern recognition receptor, Toll-like receptor 4 (TLR4).
springer.com
sci-hub.st 参考文章(51)
J. Terry Ulrich, Kent R. Myers, Monophosphoryl Lipid A as an Adjuvant Vaccine Design. ,vol. 6, pp. 495- 524 ,(1995) , 10.1007/978-1-4615-1823-5_21
Cosima Pohle, Beate Rohde-Schulz, K. Noel Masihi, Effects of Synthetic HIV Peptides, Cytokines and Monophosphoryl Lipid A on Chemiluminescence Response Immunotherapeutic Prospects of Infectious Diseases. pp. 143- 149 ,(1990) , 10.1007/978-3-642-76120-1_18
Helen Coley Nauts, Walker E. Swift, Bradley L. Coley, The treatment of malignant tumors by bacterial toxins as developed by the late William B. Coley, M.D., reviewed in the light of modern research. Cancer Research. ,vol. 6, pp. 205- 216 ,(1946)
Jessica R. Burdman, Michael F. Powell, Mark J. Newman, Vaccine design : the subunit and adjuvant approach Plenum Press. ,(1995)
M. Caroff, C. Deprun, D. Karibian, L. Szabó, Analysis of unmodified endotoxin preparations by 252Cf plasma desorption mass spectrometry. Determination of molecular masses of the constituent native lipopolysaccharides. Journal of Biological Chemistry. ,vol. 266, pp. 18543- 18549 ,(1991) , 10.1016/S0021-9258(18)55096-1
K. A. Brozek, C. R. H. Raetz, Biosynthesis of lipid A in Escherichia coli. Acyl carrier protein-dependent incorporation of laurate and myristate. Journal of Biological Chemistry. ,vol. 265, pp. 15410- 15417 ,(1990) , 10.1016/S0021-9258(18)55412-0
K. J. Drachenberg, A. W. Wheeler, P. Stuebner, F. Horak, A well-tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injections. Allergy. ,vol. 56, pp. 498- 505 ,(2001) , 10.1034/J.1398-9995.2001.056006498.X
Jay T Evans, Christopher W Cluff, David A Johnson, Michael J Lacy, David H Persing, Jory R Baldridge, Enhancement of antigen-specific immunity via the TLR4 ligands MPL adjuvant and Ribi.529 Expert Review of Vaccines. ,vol. 2, pp. 219- 229 ,(2003) , 10.1586/14760584.2.2.219
Satoshi Fukuoka, Klaus Brandenburg, Mareike Müller, Buko Lindner, Michel H.J Koch, Ulrich Seydel, Physico-chemical analysis of lipid A fractions of lipopolysaccharide from Erwinia carotovora in relation to bioactivity. Biochimica et Biophysica Acta. ,vol. 1510, pp. 185- 197 ,(2001) , 10.1016/S0005-2736(00)00347-3
David A. Johnson, C. Gregory Sowell, Craig L. Johnson, Mark T. Livesay, David S. Keegan, Michael J. Rhodes, J. Terry Ulrich, Jon R. Ward, John L. Cantrell, Valerie G. Brookshire, Synthesis and biological evaluation of a new class of vaccine adjuvants: aminoalkyl glucosaminide 4-phosphates (AGPs) Bioorganic & Medicinal Chemistry Letters. ,vol. 9, pp. 2273- 2278 ,(1999) , 10.1016/S0960-894X(99)00374-1