Kinesin family member 14 is a candidate prognostic marker for outcome of glioma patients

摘要: Abstract Background & aim : Human kinesin superfamily proteins (KIFs) are a conserved class of microtubule-dependent molecular motor with adenosine triphosphatase activity and motion characteristics. As member KIFs, KIF14 plays an important role in the regulation cell cycle mitotic progression. Deregulation has been found several human malignancies also demonstrated to be involved tumor progression related patient survival. The this study was investigate clinicopathological significance expression glioma. Methods Real-time quantitative RT-PCR assay performed detect mRNA expression, Western blot immunohistochemistry analyses were protein gliomas non-neoplastic brain tissues, respectively. Then, association immunostaining factors prognosis glioma patients statistically analyzed. Results respectively increased 5.5- 4.2-fold on average tissues relative (both P =0.008), low Karnofsky performance score (KPS) ( =0.02), high index =0.005) Ki-67 =0.008). Furthermore, both univariate multivariate Cox regression determined that overexpression effectively predicted decreased overall survival gliomas. Conclusions These findings offer first convinced evidence is tumor-specific more aggressive tumors. might function as candidate prognostic marker for