Synergistic interaction of miconazole and fluconazole at sub-MIC level on Candida albicans.
作者： Y. Mikami , A. Takahashi , K. Yazawa , K. Terao , Y. Ueno
DOI: 10.1111/J.1439-0507.1992.TB00888.X
关键词:
摘要: Zusammenfassung. Es wurde die kombinierte Wirkung zweier Azole, Miconazol und Fluconazol, auf Candida albicans untersucht. Uber Bestimmung der minimalen Hemmkonzentrationen (MHK), subinhibitorischen Konzentrationen fraktionierten konnte eine synergistische beider Antimyzetika unterhalb jeweils individuellen Hemmkonzentration aufgezeigt werden. Der fraktionierte Hemmkonzentrations-Index lag im Bereich von 0.3 bis 1.0, Synergismus war charakterisiert durch Potenzierung Fluconazol-Wirkung Miconazol. Die auch mit turbidimetrischen Methode belegt Andererseits bei C. krusei kein synergistischer Effekt gefunden. Summary. The in vitro combination effect of two azole antimycotics, miconazole and fluconazole, against was studied. When minimum (MIC) sub-minimum (sub-MIC) inhibitory concentration fractional (FIC) determinations were made, a synergistic interaction the agents at well below their individual MICs (at sub-MIC levels) evidenced. FIC index values ranged from to 1.0 synergy characterized by potentiation fluconazole activity with miconazole. also confirmed turbidometric method. On other hand, such not confirmed.
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