Anti-neutrophil antibodies in chronic hepatitis and the effect of α-interferon therapy

摘要: In 34 patients with non-A non-B, 28 type B and 11 autoimmune chronic hepatitis, anti-neutrophil antibodies were investigated using indirect immunofluorescence anti-myeloperoxidase by enzyme-linked immunosorbent assay. Granulocyte-specific antinuclear antibodies, detected in 14 advanced stages of non-A, non-B hepatitis (41%). Their presence correlated histological features disease activity but not response to interferon therapy. Within 24 h after the first dose interferon, 9 these became negative 3 more 1, 5 months. Myeloperoxidase-positive perinuclear neutrophil cytoplasmic a single patient increased reaching peak level 8 weeks decreasing thereafter. B, all before during 6 months (55%), myeloperoxidase-negative high titers. The association granulocyte-specific anti-nuclear support hypothesis that C virus infection might trigger humoral response. appear as another marker autoimmunity.