Breakdown and Release of Myofilament Proteins During Ischemia and Ischemia/Reperfusion in Rat Hearts Identification of Degradation Products and Effects on the pCa-Force Relation

作者: Jennifer E. Van Eyk , Francis Powers , William Law , Catherine Larue , Robert S. Hodges

DOI: 10.1161/01.RES.82.2.261

关键词:

摘要: Abstract—Our objective in experiments reported here was to identify myofilament proteins of rat hearts either lost or degraded by cardiac ischemia (15- 60-minute duration) with and without 45 mi...

参考文章(52)
R. John Solaro, Bo-Sheng Pan, Control and Modulation of Contractile Activity of Cardiac Myofilaments Springer, Boston, MA. pp. 291- 303 ,(1989) , 10.1007/978-1-4613-0873-7_14
Y. Yamahara, B. Ohta, M. Inoue, T. Tatsumi, M. Nakagawa, J. Asayama, H. Miyazaki, T. Matsumoto, M. Kobara, D. Inoue, Release kinetics and correlation with hemodynamic dysfunction of cardiac troponin T in coronary effluent from isolated rat hearts during reperfusion Basic Research in Cardiology. ,vol. 88, pp. 307- 313 ,(1993) , 10.1007/BF00800637
A H Wu, M B Perryman, Clinical applications of muscle enzymes and proteins. Current Opinion in Rheumatology. ,vol. 4, pp. 815- 820 ,(1992)
MK Reddy, JD Etlinger, M Rabinowitz, DA Fischman, R Zak, Removal of Z-lines and alpha-actinin from isolated myofibrils by a calcium-activated neutral protease. Journal of Biological Chemistry. ,vol. 250, pp. 4278- 4284 ,(1975) , 10.1016/S0021-9258(19)41414-2
D.E. Goll, W.R. Dayton, I. Singh, R.M. Robson, Studies of the alpha-actinin/actin interaction in the Z-disk by using calpain. Journal of Biological Chemistry. ,vol. 266, pp. 8501- 8510 ,(1991) , 10.1016/S0021-9258(18)93003-6
F Di Lisa, R De Tullio, F Salamino, R Barbato, E Melloni, N Siliprandi, S Schiaffino, S Pontremoli, Specific degradation of troponin T and I by mu-calpain and its modulation by substrate phosphorylation. Biochemical Journal. ,vol. 308, pp. 57- 61 ,(1995) , 10.1042/BJ3080057
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Wei Dong Gao, Dan Atar, Yongge Liu, Nestor Gustavo Perez, Anne M. Murphy, Eduardo Marban, Role of Troponin I Proteolysis in the Pathogenesis of Stunned Myocardium Circulation Research. ,vol. 80, pp. 393- 399 ,(1997) , 10.1161/01.RES.0000435855.49359.47