Mice Lacking NCF1 Exhibit Reduced Growth of Implanted Melanoma and Carcinoma Tumors

摘要: The NADPH oxidase 2 (NOX2) complex is a professional producer of reactive oxygen species (ROS) and mainly expressed in phagocytes. While the activity NOX2 essential for immunity against pathogens protection autoimmunity, its role development malignant tumors remains unclear. We compared wild type Ncf1 (m1J) mutated mice, which lack functional complex, four different tumor models. mice developed significantly smaller two melanoma models B16 cells expressing hematopoietic growth factor FLT3L or luciferase reporter were used. fewer Lewis Lung Carcinoma (LLC) tumors, but that did develop, grew at pace was similar to mice. In spontaneously arising prostate carcinoma model (TRAMP), not affected. ROS-mediated associated with increased production immunity-associated cytokines. A significant increase Th2 cytokines observed LLC model. Our present data show ROS regulate rejection antigenic B16-luc whereas do support intrinsically generated tumors.