Involvement of lncRNA-1700040D17Rik in Th17 cell differentiation and the pathogenesis of EAE
作者： Wei Guo , Wen Lei , Dongmei Yu , Yaoyao Ge , Yucong Chen
DOI: 10.1016/J.INTIMP.2017.03.014
关键词:
摘要: IL-23/STAT3 signaling pathway is a key process in Th17 cell differentiation, and cells are closely related to the development of autoimmune diseases. We previously designed prepared rhIL23R-CHR protein antagonize endogenous IL-23, showing effectiveness treatment experimental encephalomyelitis (EAE) mice. To further elucidate mechanism action, mouse lncRNA microarray was used screen expression profiles lncRNAs, particular lncRNA, 1700040D17Rik found down-regulate EAE model its significantly increased after by rhIL23R-CHR. The function revealed associate with differentiation through regulation transcription factor RORγt. Together, responsible for effects balance immune responses, has potential serve as therapeutic target or biomarker
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