Awakening properties of modafinil without paradoxical sleep rebound: comparative study with amphetamine in the rat.
作者： M. Tourev , M. Sallanon-Moulin , M. Jouvet
DOI: 10.1016/0304-3940(95)11448-6
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摘要: Abstract We have studied the effect of modafinil and amphetamine, two waking drugs, on sleep-wake cycle Sprague-Dawley rat. Both (64 or 128 mg/kg) amphetamine (2.5 5 cause a dose dependent increase in wakefulness. However, wakefulness is followed by paradoxical sleep rebound injection day, whereas does not produce this effect. In modafinil-treated rats, pattern post-injection day similar to that controls, while amphetamine-treated rats modified.
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