Evaluation of DNA damage using 3 comet assay parameters in workers occupationally exposed to lead.
作者： Zelıha Kayaaltı , İlknur Yavuz , Esma Söylemez , Ayşegül Bacaksız , Engın Tutkun
DOI: 10.1080/19338244.2013.787964
关键词:
摘要: The aim of this study was to investigate the association between DNA damage and blood lead levels in individuals occupationally exposed lead. To evaluate association, 61 workers were monitored terms lymphocytes. measured according 3 comet assay parameters, including tail intensity (TI), moment (TM), (DNAt). A statistically significant positive correlation found TI, TM, DNAt (p <.01). Smoking had independent effects on damage. difference observed smokers nonsmokers regards parameters <.05). In addition, be significantly higher than nonsmoking Our results show that exposure induces genotoxic peripheral lymphocytes, as by assays.
sci-hub.se 参考文章(43)
George N Tzanakakis, Aristidis M Tsatsakis, Stamatis Belivanis, Nikolas C Papanikolaou, Eleftheria G Hatzidaki, Lead toxicity update. A brief review. Medical Science Monitor. ,vol. 11, ,(2005)
Abraham T. Philip, Benjamin Gerson, Lead poisoning--Part I. Incidence, etiology, and toxicokinetics. Clinics in Laboratory Medicine. ,vol. 14, pp. 423- 444 ,(1994) , 10.1016/S0272-2712(18)30386-X
H Fu, P Boffetta, Cancer and occupational exposure to inorganic lead compounds: a meta-analysis of published data. Occupational and Environmental Medicine. ,vol. 52, pp. 73- 81 ,(1995) , 10.1136/OEM.52.2.73
Julia García-Lestón, Joana Roma-Torres, Maria Vilares, Rui Pinto, João Prista, João Paulo Teixeira, Olga Mayan, João Conde, Marta Pingarilho, Jorge Francisco Gaspar, Eduardo Pásaro, Josefina Méndez, Blanca Laffon, Genotoxic effects of occupational exposure to lead and influence of polymorphisms in genes involved in lead toxicokinetics and in DNA repair Environment International. ,vol. 43, pp. 29- 36 ,(2012) , 10.1016/J.ENVINT.2012.03.001
M. Sirover, L. Loeb, Infidelity of DNA synthesis in vitro: screening for potential metal mutagens or carcinogens. Science. ,vol. 194, pp. 1434- 1436 ,(1976) , 10.1126/SCIENCE.1006310
Stefano Bonassi, Angelo Abbondandolo, Lamberto Camurri, Leda Dal Prá, Marcella De Ferrari, Francesca Degrassi, Alessandra Forni, Laura Lamberti, Cecilia Lando, Paola Padovani, Isabella Sbrana, Daniela Vecchio, Riccardo Puntoni, Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study Cancer Genetics and Cytogenetics. ,vol. 79, pp. 133- 135 ,(1995) , 10.1016/0165-4608(94)00131-T
J Palus, K Rydzynski, E Dziubaltowska, K Wyszynska, A.T Natarajan, R Nilsson, Genotoxic effects of occupational exposure to lead and cadmium. Mutation Research-genetic Toxicology and Environmental Mutagenesis. ,vol. 540, pp. 19- 28 ,(2003) , 10.1016/S1383-5718(03)00167-0
K. Danadevi, Roya Rozati, B. Saleha Banu, P. Hanumanth Rao, Paramjit Grover, DNA damage in workers exposed to lead using comet assay. Toxicology. ,vol. 187, pp. 183- 193 ,(2003) , 10.1016/S0300-483X(03)00054-4
Paramjit Grover, P.V. Rekhadevi, K. Danadevi, S.B. Vuyyuri, M. Mahboob, M.F. Rahman, Genotoxicity evaluation in workers occupationally exposed to lead. International Journal of Hygiene and Environmental Health. ,vol. 213, pp. 99- 106 ,(2010) , 10.1016/J.IJHEH.2010.01.005
Edwin A. Popenoe, Max A. Schmaeler, Interaction of human DNA polymerase β with ions of copper, lead, and cadmium Archives of Biochemistry and Biophysics. ,vol. 196, pp. 109- 120 ,(1979) , 10.1016/0003-9861(79)90557-5