White Matter Hyperintensity Load Modulates Brain Morphometry and Brain Connectivity in Healthy Adults: A Neuroplastic Mechanism?

摘要: White matter hyperintensities (WMHs) are acquired lesions that accumulate and disrupt neuron-to-neuron connectivity. We tested the associations between WMH load (1) regional grey volumes (2) functional connectivity of resting-state networks, in a sample 51 healthy adults. Specifically, we focused on positive (more damage, more volume/connectivity) to investigate potential route adaptive plasticity. WMHs were quantified with an automated procedure. Voxel-based morphometry was carried out model matter. An independent component analysis run extract anterior posterior default-mode network, salience left right frontoparietal visual network. Each corrected for age, global levels atrophy, indices brain cognitive reserve. Positive found network Within association mediotemporal-limbic complex. parietal cortex. The findings support suggestion that, even absence overt disease, actuates compensatory (neuroplastic) response accumulation WMH, leading increases modified