CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection.

摘要: The ability of Listeria monocytogenes to gain access the cytoplasm infected cells results in processing and presentation bacterial Ags through MHC class I pathway. As a result, CD8 T are most effective mediators acquired immunity mouse model L. infection. specific for single nonamer epitope derived from secreted virulence factor listeriolysin O (LLO) can protect H-2d mice against lethal Bacteria lacking LLO avirulent do not elicit protective mice. Thus, failure minus could be caused either by their inability enter or lack LLO-derived peptide epitopes. In this report we provide evidence that restricted with specificity another protein, p60 molecule, Our studies further demonstrate LLO-dependent induction bacterium cytoplasm. addition, these support hypothesis proteins important targets cell-mediated immunity.