Mechanisms responsible for ERBB2 gene overexpression in human breast and non-breast cancer cells. The role of AP-2 transcription factors

摘要: Summary The ERBB2 gene codes for p185 erbB2 , a transmembrane protein with intrinsic tyrosine kinase activity. P185 is member of the EGFR family growth factor receptors. expressed in embryonic and adult cells its function necessary throughout entire life. overexpressed significant proportion human breast cancers where it correlated to poor prognosis patient. also non-breast but researchers disagree on prognostic significance overexpression these cancers. Gene amplification increased transcription rates account very high levels accumulated cancer cells. In moderate increase level due transcriptional deregulation alone. mechanisms responsible not well understood. molecular have been investigated mostly this paper we review data from literature our own results involvement AP-2 factors We conclude that contribute fraction contrast, are expression analyzed.