Native lung volume reduction surgery relieves functional graft compression after single-lung transplantation for chronic obstructive pulmonary disease.

摘要: Objective Single-lung transplantation is an accepted treatment for end-stage lung disease caused by chronic obstructive pulmonary disease. A complication unique to single-lung graft dysfunction due compression native hyperinflation. We hypothesized that patients with functional compromise from hyperinflation would benefit volume reduction surgery. Methods The charts of all undergoing were reviewed surgery their lung. Data regarding length stay, surgical morbidity and mortality, overall survival, type surgery, function recorded evaluate the effect Results Between February 1992 May 2007, 206 transplantations performed Ten (5%) had clinically significant After excluding other causes decline, these underwent a modified between 12 142 months after (mean, 50 months). Lung consisted anatomic resection. Two (20%) 10 died during hospitalization. Of remaining 8 patients, 7 (87.5%) have demonstrated improvement on basis forced expiratory in 1 second improving 12% 200% (mean improvement, 57%). Within 6 mean 6-minute walk values improved significantly (866 1055 feet), whereas desaturation exertion decreased significantly. Conclusions means formal lobectomy appears feasible. Additionally, improvements can be accomplished nearly properly selected patients. should considered decreasing