Continued Utility of Single-Lung Transplantation in Select Populations: Chronic Obstructive Pulmonary Disease

摘要: Background The use of single lung transplantation (SLTx) for chronic obstructive pulmonary disease is often viewed as inferior therapy compared with bilateral (BLTx). We hypothesized from our experience that subpopulations recipients emphysema exist in which SLTx represents equivalent to BLTx, therefore allowing more patients access transplantation. Methods Consecutive undergoing LTx between 1992 and 2012 at a institution were identified analyzed retrospectively. A similar cohort the United Network Organ Sharing (UNOS) national database was comparison. Five-year survival receiving those BLTx using Kaplan-Meier curves log-rank tests. Results Two hundred thirty-six meeting criteria our institution. six underwent SLTx, 30 BLTx. single-center (53.2% ± 3.6%) (56.7% 10.2%) not significantly different ( p  = 0.753). included 7,256 selection criteria, 4,408 2,848 among cohorts lower (46.4% 0.8%) (55.9% 1.1%) 0.539). Conclusions after comparable UNOS database. Further study should focus on mechanism behind these improved outcomes. Given potential larger number life-years saved, continue be considered a therapeutic option appropriately selected (COPD).