Lung transplantation for chronic obstructive pulmonary disease: past, present, and future directions.

摘要: Purpose of review Lung transplantation offers an effective treatment modality for patients with end-stage chronic obstructive pulmonary disease (COPD). The exact determination when to refer, list, and offer transplant as well the preferred procedure type remains unclear. Additionally, there are special considerations specific COPD being considered lung transplantation, including implications single on cancer risk, native hyperinflation, overall survival. Recent findings International Society Heart Transplantation's most recent recommendations rely assessment severity based BODE index. Despite lack evidence supporting a mortality benefit bilateral over patients, majority transplants performed in this population remain bilateral. Some concerns possibility de novo hemodynamic physiologic acute hyperinflation. Summary common worldwide indication transplantation. Ongoing study is still required assess survival quality life impact patient population.