Inhibition of PPARα Induces Cell Cycle Arrest and Apoptosis, and Synergizes with Glycolysis Inhibition in Kidney Cancer Cells

作者: Omran Abu Aboud , Hiromi I. Wettersten , Robert H. Weiss

DOI: 10.1371/JOURNAL.PONE.0071115

关键词:

摘要: … of kidney cancer using metabolomics methods, we found metabolic signatures of PPARα … Whether this finding is due to causality of PPARα activation in oncogenesis or whether it is …

参考文章(42)
Chuan-bing Zang, Kurt Possinger, Hong-yu Liu, Shao-guang Fan, Elena Elstner, Da-chuan Liu, A novel PPAR alpha/gamma dual agonist inhibits cell growth and induces apoptosis in human glioblastoma T98G cells. Acta Pharmacologica Sinica. ,vol. 25, pp. 1312- 1319 ,(2004)
B. Amati, T.D. Littlewood, G.I. Evan, H. Land, The c‐Myc protein induces cell cycle progression and apoptosis through dimerization with Max. The EMBO Journal. ,vol. 12, pp. 5083- 5087 ,(1993) , 10.1002/J.1460-2075.1993.TB06202.X
Arie S. Belldegrun, Tobias Klatte, Brian Shuch, Jeffrey C. LaRochelle, David C. Miller, Jonathan W. Said, Stephen B. Riggs, Nazy Zomorodian, Fairooz F. Kabbinavar, Jean B. deKernion, Allan J. Pantuck, Cancer-specific survival outcomes among patients treated during the cytokine era of kidney cancer (1989-2005) Cancer. ,vol. 113, pp. 2457- 2463 ,(2008) , 10.1002/CNCR.23851
Sander Kersten, Béatrice Desvergne, Walter Wahli, Roles of PPARs in health and disease Nature. ,vol. 405, pp. 421- 424 ,(2000) , 10.1038/35013000
P. Steiner, A. Philipp, J. Lukas, D. Godden-Kent, M. Pagano, S. Mittnacht, J. Bartek, M. Eilers, Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes. The EMBO Journal. ,vol. 14, pp. 4814- 4826 ,(1995) , 10.1002/J.1460-2075.1995.TB00163.X
SANDER KERSTEN, STÉPHANE MANDARD, PASCAL ESCHER, FRANK J. GONZALEZ, SHERRIE TAFURI, BÉATRICE DESVERGNE, WALTER WAHLI, The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism. The FASEB Journal. ,vol. 15, pp. 1971- 1978 ,(2001) , 10.1096/FJ.01-0147COM
R.H. Weiss, P.-Y. Lin, Kidney cancer: identification of novel targets for therapy. Kidney International. ,vol. 69, pp. 224- 232 ,(2006) , 10.1038/SJ.KI.5000065
Maryam Rakhshandehroo, Bianca Knoch, Michael Müller, Sander Kersten, Peroxisome Proliferator-Activated Receptor Alpha Target Genes Ppar Research. ,vol. 2010, pp. 1- 20 ,(2010) , 10.1155/2010/612089
Wong-Ho Chow, Linda M. Dong, Susan S. Devesa, Epidemiology and risk factors for kidney cancer Nature Reviews Urology. ,vol. 7, pp. 245- 257 ,(2010) , 10.1038/NRUROL.2010.46