Efficacy of tolfenamic acid and meloxicam in the control of postoperative pain following ovariohysterectomy in the cat.

摘要: Summary Objective The hypothesis was that Visual Analog Scale (VAS) scores would be lower, and mechanical wound thresholds (MWT) higher, in cats receiving tolfenamic acid compared to those placebo the postoperative period following elective ovariohysterectomy. Animals Sixty-nine client-owned cats. Methods A prospective, randomized, blinded placebo-controlled study performed which underwent ovariohysterectomy preoperative acid, meloxicam, or placebo. second dose of same analgesic administered 24 hours postoperatively. Assessments were made 1-hour before induction 1, 2, 4, 6, 22, 25 Pain assessed by a observer using Numerical Rating (NRS) VAS scales. MWT measured force-measuring device. Group comparison one-way anova chi-squared test for qualitative quantitative data, respectively, mixed model repeated measurements (p Results Sixty-five included study. There no differences between groups at baseline. treatment effect on NRS 22 hours. meloxicam group less painful than controls 6 hours; both pain sedation. number animals rescue analgesia did not differ groups. MWT; significantly higher observed all time points. Conclusions Preoperative reduced sensitivity cat. Clinical relevance Tolfenamic preoperatively provided similar lasting Mechanical may better way evaluating nonsteroidal anti-inflammatory drugs