Host-parasite relationship in echinococcosis. I. Parasite biomass and antibody response in three strains of inbred mice against graded doses of Echinococcus multilocularis cysts.

摘要: Susceptibility studies in C57L, DBA, and C57B1 mice, infected intraperitoneally with 1, 5, 20, 100 cysts of Echinococcus multilocularis, showed a significant difference the cyst weights, after 12-week period. With all 4 inocula C57L mice supported greater larval load than DBA mice. Sera obtained at 2, 4, 8, 12 weeks postinfection (p.i.) from these hemagglutinating antibodies (HAA) only p.i. 1and 5-cyst groups but much earlier 20and 100-cyst groups. similar HAA titers had 1 to precipitin bands depending on stage infection. These results are discussed regard possible nonprotective role echinococcosis. No specific data available functional relationship between immune mechanisms host either unilocular (Echinococcus granulosus) or alveolar (E. multilocularis) types hydatid disease. The former species has been continuing interest because its worldwide distribution consequent higher incidence infection man animals (Kagan, 1968; Gore et al., 1970; Williams 1971). In recent years screening experimental for laboratory maintenance histogenesis E. multilocularis have described (Rausch, 1954; Yamashita 1958; Lubinsky, 1964; Webster Cameron, 1961), quantitative parasite burden, antibody response, ensuing immunopathological changes response various infective inbred strains lacking. development an model using strain establishment measurable parameters order study or, conversely, apparent inability suitable contain rapid proliferation elimination cysts, appear be order. This paper reports biomass three against variable