Genetic control of immune responses to parasites: immunity to Trichuris muris in inbred and random-bred strains of mice.

摘要: A comparison has been made of the responses random-bred CFLP and inbred NIH mice to infection with Trichuris muris . Random-bred showed greater variation in worm burdens less uniformity expulsion. Irradiation prior reduced variation, but did not increase mean level above that shown by most susceptible unirradiated mice. In mice, however, irradiation raised all The factors responsible for between came into play after fifth day were inactivated cortisone acetate. It is suggested these are immunologically mediated under direct genetic control. Uniformity expulsion therefore seen as a consequence uniformity; variability variation. time was found differ markedly strains Hybrid progeny characteristic parental strain rapid expulsion; resistance inherited dominant characteristic. control immunity T. discussed context antibody- cell-mediated components process.