作者: Nicholas Li-Xun Syn , Wei-Peng Yong , Boon-Cher Goh , Soo-Chin Lee
DOI: 10.1080/17425255.2016.1196187
关键词:
摘要: ABSTRACTIntroduction: Tumour molecular profiling has been at the crossroads of large-scale integrative genomic studies and major clinical trials over past 5 years provided roadmaps for better disease stratification therapeutic management.Areas covered: We review landscape precision oncology in Asia, Europe United States, emerging insights gained from recently reported such as SHIVA CUSTOM trials. Changes portraits human cancers immune contexture tumor microenvironment during treatment may predict course progression, including development resistance. ‘Liquid biopsy’ approaches that harness circulating cells, cell-free DNA exosomes provide a non-invasive means monitoring parent real-time. Several signatures are being evaluated biomarkers immunologic approaches, mismatch-repair deficiency status nonsynonymous mutatio...