Evolving landscape of tumor molecular profiling for personalized cancer therapy: a comprehensive review

作者: Nicholas Li-Xun Syn , Wei-Peng Yong , Boon-Cher Goh , Soo-Chin Lee

DOI: 10.1080/17425255.2016.1196187

关键词:

摘要: ABSTRACTIntroduction: Tumour molecular profiling has been at the crossroads of large-scale integrative genomic studies and major clinical trials over past 5 years provided roadmaps for better disease stratification therapeutic management.Areas covered: We review landscape precision oncology in Asia, Europe United States, emerging insights gained from recently reported such as SHIVA CUSTOM trials. Changes portraits human cancers immune contexture tumor microenvironment during treatment may predict course progression, including development resistance. ‘Liquid biopsy’ approaches that harness circulating cells, cell-free DNA exosomes provide a non-invasive means monitoring parent real-time. Several signatures are being evaluated biomarkers immunologic approaches, mismatch-repair deficiency status nonsynonymous mutatio...

参考文章(103)
Monica Arnedos, Cecile Vicier, Sherene Loi, Celine Lefebvre, Stefan Michiels, Herve Bonnefoi, Fabrice Andre, Precision medicine for metastatic breast cancer—limitations and solutions Nature Reviews Clinical Oncology. ,vol. 12, pp. 693- 704 ,(2015) , 10.1038/NRCLINONC.2015.123
Andrew J Gentles, Aaron M Newman, Chih Long Liu, Scott V Bratman, Weiguo Feng, Dongkyoon Kim, Viswam S Nair, Yue Xu, Amanda Khuong, Chuong D Hoang, Maximilian Diehn, Robert B West, Sylvia K Plevritis, Ash A Alizadeh, The prognostic landscape of genes and infiltrating immune cells across human cancers Nature Medicine. ,vol. 21, pp. 938- 945 ,(2015) , 10.1038/NM.3909
Sonia A. Melo, Linda B. Luecke, Christoph Kahlert, Agustin F. Fernandez, Seth T. Gammon, Judith Kaye, Valerie S. LeBleu, Elizabeth A. Mittendorf, Juergen Weitz, Nuh Rahbari, Christoph Reissfelder, Christian Pilarsky, Mario F. Fraga, David Piwnica-Worms, Raghu Kalluri, Glypican-1 identifies cancer exosomes and detects early pancreatic cancer Nature. ,vol. 523, pp. 177- 182 ,(2015) , 10.1038/NATURE14581
Theodor Boveri, Zur Frage der Entstehung maligner Tumoren G. Fischer. ,(1914)
Ann-Marie Patch, Elizabeth L Christie, Dariush Etemadmoghadam, Dale W Garsed, Joshy George, Sian Fereday, Katia Nones, Prue Cowin, Kathryn Alsop, Peter J Bailey, Karin S Kassahn, Felicity Newell, Michael CJ Quinn, Stephen Kazakoff, Kelly Quek, Charlotte Wilhelm-Benartzi, Ed Curry, Huei San Leong, Australian Ovarian Cancer Study Group, Anne Hamilton, Linda Mileshkin, George Au-Yeung, Catherine Kennedy, Jillian Hung, Yoke-Eng Chiew, Paul Harnett, Michael Friedlander, Michael Quinn, Jan Pyman, Stephen Cordner, Patricia O’Brien, Jodie Leditschke, Greg Young, Kate Strachan, Paul Waring, Walid Azar, Chris Mitchell, Nadia Traficante, Joy Hendley, Heather Thorne, Mark Shackleton, David K Miller, Gisela Mir Arnau, Richard W Tothill, Timothy P Holloway, Timothy Semple, Ivon Harliwong, Craig Nourse, Ehsan Nourbakhsh, Suzanne Manning, Senel Idrisoglu, Timothy JC Bruxner, Angelika N Christ, Barsha Poudel, Oliver Holmes, Matthew Anderson, Conrad Leonard, Andrew Lonie, Nathan Hall, Scott Wood, Darrin F Taylor, Qinying Xu, J Lynn Fink, Nick Waddell, Ronny Drapkin, Euan Stronach, Hani Gabra, Robert Brown, Andrea Jewell, Shivashankar H Nagaraj, Emma Markham, Peter J Wilson, Jason Ellul, Orla McNally, Maria A Doyle, Ravikiran Vedururu, Collin Stewart, Ernst Lengyel, John V Pearson, Nicola Waddell, Anna deFazio, Sean M Grimmond, David DL Bowtell, Whole-genome characterization of chemoresistant ovarian cancer Nature. ,vol. 521, pp. 489- 494 ,(2015) , 10.1038/NATURE14410
Gabriel N. Hortobagyi, David Chen, Martine Piccart, Hope S. Rugo, Howard A. Burris, Kathleen I. Pritchard, Mario Campone, Shinzaburo Noguchi, Alejandra T. Perez, Ines Deleu, Mikhail Shtivelband, Norikazu Masuda, Shaker Dakhil, Ian Anderson, Douglas M. Robinson, Wei He, Abhishek Garg, E. Robert McDonald, Hans Bitter, Alan Huang, Tetiana Taran, Thomas Bachelot, Fabienne Lebrun, David Lebwohl, José Baselga, Correlative Analysis of Genetic Alterations and Everolimus Benefit in Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer: Results From BOLERO-2 Journal of Clinical Oncology. ,vol. 34, pp. 419- 426 ,(2016) , 10.1200/JCO.2014.60.1971
Andrew J Gentles, Scott V Bratman, Luke J Lee, Jeremy P Harris, Weiguo Feng, Ramesh V Nair, David B Shultz, Viswam S Nair, Chuong D Hoang, Robert B West, Sylvia K Plevritis, Ash A Alizadeh, Maximilian Diehn, None, Integrating Tumor and Stromal Gene Expression Signatures With Clinical Indices for Survival Stratification of Early-Stage Non–Small Cell Lung Cancer Journal of the National Cancer Institute. ,vol. 107, ,(2015) , 10.1093/JNCI/DJV211
Feriyl Bhaijee, Thomas Huebner, Ralph H. Hruban, Laura D. Wood, Nathan Cuka, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, Shibin Zhou, Toby C. Cornish, Janis M. Taube, Robert A. Anders, James R. Eshleman, Bert Vogelstein, Luis A. Diaz, Dung T. Le, Jennifer N. Uram, Hao Wang, Bjarne R. Bartlett, Holly Kemberling, Aleksandra D. Eyring, Andrew D. Skora, Brandon S. Luber, Nilofer S. Azad, Dan Laheru, Barbara Biedrzycki, Ross C. Donehower, Atif Zaheer, George A. Fisher, Todd S. Crocenzi, James J. Lee, Steven M. Duffy, Richard M. Goldberg, Albert de la Chapelle, Minori Koshiji, PD-1 Blockade in Tumors with Mismatch-Repair Deficiency The New England Journal of Medicine. ,vol. 372, pp. 2509- 2520 ,(2015) , 10.1056/NEJMOA1500596
Katherine A Hoadley, Christina Yau, Denise M Wolf, Andrew D Cherniack, David Tamborero, Sam Ng, Max DM Leiserson, Beifang Niu, Michael D McLellan, Vladislav Uzunangelov, Jiashan Zhang, Cyriac Kandoth, Rehan Akbani, Hui Shen, Larsson Omberg, Andy Chu, Adam A Margolin, Laura J Van’t Veer, Nuria Lopez-Bigas, Peter W Laird, Benjamin J Raphael, Li Ding, A Gordon Robertson, Lauren A Byers, Gordon B Mills, John N Weinstein, Carter Van Waes, Zhong Chen, Eric A Collisson, Christopher C Benz, Charles M Perou, Joshua M Stuart, None, Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin Cell. ,vol. 158, pp. 929- 944 ,(2014) , 10.1016/J.CELL.2014.06.049