Correlative Analysis of Genetic Alterations and Everolimus Benefit in Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer: Results From BOLERO-2
作者： Gabriel N. Hortobagyi , David Chen , Martine Piccart , Hope S. Rugo , Howard A. Burris
关键词:
摘要: PurposeTo explore the genetic landscape of tumors from patients enrolled on BOLERO-2 trial to identify potential correlations between alterations and efficacy everolimus treatment. The has previously demonstrated that addition exemestane prolonged progression-free survival by more than twofold in with hormone receptor–positive, human epidermal growth factor receptor 2–negative, advanced breast cancer treated nonsteroidal aromatase inhibitors.Patients MethodsNext-generation sequencing was used analyze status cancer-related genes 302 archival tumor specimens representative study population. Correlations most common somatic degree chromosomal instability, treatment effect were investigated.ResultsProgression-free benefit maintained regardless alteration PIK3CA, FGFR1, CCND1 or pathways ...
elsevier.com
ulb.ac.be
sci-hub.se 参考文章(38)
Natalie Jones, Françoise Bonnet, Sana Sfar, Marie Lafitte, Delfine Lafon, Ghislaine Sierankowski, Véronique Brouste, Guillaume Banneau, Christine Tunon de Lara, Marc Debled, Gaëtan MacGrogan, Michel Longy, Nicolas Sevenet, Comprehensive analysis of PTEN status in breast carcinomas. International Journal of Cancer. ,vol. 133, pp. 323- 334 ,(2013) , 10.1002/IJC.28021
Philip J Stephens, Patrick S Tarpey, Helen Davies, Peter Van Loo, Chris Greenman, David C Wedge, Serena Nik-Zainal, Sancha Martin, Ignacio Varela, Graham R Bignell, Lucy R Yates, Elli Papaemmanuil, David Beare, Adam Butler, Angela Cheverton, John Gamble, Jonathan Hinton, Mingming Jia, Alagu Jayakumar, David Jones, Calli Latimer, King Wai Lau, Stuart McLaren, David J McBride, Andrew Menzies, Laura Mudie, Keiran Raine, Roland Rad, Michael Spencer Chapman, Jon Teague, Douglas Easton, Anita Langerød, Oslo Breast Cancer Consortium (OSBREAC) Karesen Rolf 34 35 Schlichting Ellen 34 Naume Bjorn 35 36 Sauer Torill 35 37 Ottestad Lars 36, Ming Ta Michael Lee, Chen-Yang Shen, Benita Tan Kiat Tee, Bernice Wong Huimin, Annegien Broeks, Ana Cristina Vargas, Gulisa Turashvili, John Martens, Aquila Fatima, Penelope Miron, Suet-Feung Chin, Gilles Thomas, Sandrine Boyault, Odette Mariani, Sunil R Lakhani, Marc van de Vijver, Laura van ‘t Veer, John Foekens, Christine Desmedt, Christos Sotiriou, Andrew Tutt, Carlos Caldas, Jorge S Reis-Filho, Samuel AJR Aparicio, Anne Vincent Salomon, Anne-Lise Børresen-Dale, Andrea L Richardson, Peter J Campbell, P Andrew Futreal, Michael R Stratton, None, The landscape of cancer genes and mutational processes in breast cancer Nature. ,vol. 486, pp. 400- 404 ,(2012) , 10.1038/NATURE11017
Amaury G. Dumont, Sarah N. Dumont, Jonathan C. Trent, The favorable impact of PIK3CA mutations on survival: an analysis of 2587 patients with breast cancer. Chinese Journal of Cancer. ,vol. 31, pp. 327- 334 ,(2012) , 10.5732/CJC.012.10032
S S Kwek, R Roy, H Zhou, J Climent, J A Martinez-Climent, J Fridlyand, D G Albertson, Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis. Oncogene. ,vol. 28, pp. 1892- 1903 ,(2009) , 10.1038/ONC.2009.34
G. Iyer, A. J. Hanrahan, M. I. Milowsky, H. Al-Ahmadie, S. N. Scott, M. Janakiraman, M. Pirun, C. Sander, N. D. Socci, I. Ostrovnaya, A. Viale, A. Heguy, L. Peng, T. A. Chan, B. Bochner, D. F. Bajorin, M. F. Berger, B. S. Taylor, D. B. Solit, Genome Sequencing Identifies a Basis for Everolimus Sensitivity Science. ,vol. 338, pp. 221- 221 ,(2012) , 10.1126/SCIENCE.1226344
Scott L Carter, Aron C Eklund, Isaac S Kohane, Lyndsay N Harris, Zoltan Szallasi, None, A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers Nature Genetics. ,vol. 38, pp. 1043- 1048 ,(2006) , 10.1038/NG1861
C. Shao, L. Deng, O. Henegariu, L. Liang, P. J. Stambrook, J. A. Tischfield, Chromosome instability contributes to loss of heterozygosity in mice lacking p53. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 7405- 7410 ,(2000) , 10.1073/PNAS.97.13.7405
Roger P. A'Hern, Mariam Jamal-Hanjani, A. Marcell Szász, Stephen R. D. Johnston, Jorge S. Reis-Filho, Rebecca Roylance, Charles Swanton, Taxane benefit in breast cancer--a role for grade and chromosomal stability. Nature Reviews Clinical Oncology. ,vol. 10, pp. 357- 364 ,(2013) , 10.1038/NRCLINONC.2013.67
Min Hye Jang, Eun Joo Kim, Yoomi Choi, Hee Eun Lee, Yu Jung Kim, Jee Hyun Kim, Eunyoung Kang, Sung-Won Kim, In Ah Kim, So Yeon Park, FGFR1 is amplified during the progression of in situ to invasive breast carcinoma. Breast Cancer Research. ,vol. 14, pp. 1- 12 ,(2012) , 10.1186/BCR3239
Weiyi Toy, Yang Shen, Helen Won, Bradley Green, Rita A Sakr, Marie Will, Zhiqiang Li, Kinisha Gala, Sean Fanning, Tari A King, Clifford Hudis, David Chen, Tetiana Taran, Gabriel Hortobagyi, Geoffrey Greene, Michael Berger, José Baselga, Sarat Chandarlapaty, ESR1 ligand-binding domain mutations in hormone-resistant breast cancer Nature Genetics. ,vol. 45, pp. 1439- 1445 ,(2013) , 10.1038/NG.2822