Lower Digit Symbol Substitution Score in the Oldest Old is Related to Magnetization Transfer and Diffusion Tensor Imaging of the White Matter

摘要: Background: Slowing information processing is common among community-dwelling elderly and it predicts greater mortality disability risk. related to brain macro-structural abnormalities. Specifically, global atrophy small vessel disease of the white matter have been associated slower speed. However, with such abnormalities can maintain The roles micro-structure for slow in very old adults living community uncertain, as epidemiological studies relating these markers cognition context other health characteristics are sparse. Hypothesis: Information cross-sectionally independent overt also characteristics. Methods: Imaging indices (diffusion tensor imaging, DTI, magnetization transfer MTI), macro-structure (white hyperintensities, gray volume), Digit Symbol Substitution Test (DSST) were measured 272 (mean age 83 years old, 43% men, 40% Black) community. Results: DTI- MTI-indices from normal appearing not DSST score hyperintensities volumes. Associations age, race, gender, mini-mental score, systolic blood pressure, prevalent myocardial infarction. Interpretation: DTI MTI indicators speed this cohort Since slowing a potent index disability, may serve biomarkers prevention or treatment trials disability.