Frontal gray matter atrophy in middle aged adults with type 1 diabetes is independent of cardiovascular risk factors and diabetes complications

摘要: Abstract Aims To determine if regional gray matter volume (GMV) differences in middle-aged adults with and without type-1 diabetes (T1D) are localized areas most vulnerable to aging, e.g. fronto-subcortical networks; these explained by cardiovascular risk factors complications. Methods Regional GMV was computed using 3 T MRI of 104 a childhood onset T1D (mean age: 49 ± 7 duration: 41 ± 6 years) 151 40 ± 6). A Bonferroni threshold (n = 45, p ≤ 0.001) applied account for multiple between-group comparisons analyses were repeated an age- gender-matched subset participants controls (n = 44 each group, mean age [SD] range: 44.0, [4.3], 17.4 44.6 17.0, respectively). Results Compared controls, patients had smaller the frontal lobe (6% 19% smaller) adjacent supramarginal postcentral gyri (8% 13% smaller). Between-group independent age, waist circumference, systolic blood pressure, fasting total cholesterol smoking status similar sensitivity restricted participants. Associations between complications not significant. Conclusions These findings extend notion accelerated brain aging adults. The pathophysiology atrophy its impact on future development disability dementia need further study, especially as progress older age.