Diagnostic and prognostic potential of serum miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429 in ovarian cancer patients.

摘要: Owing to late diagnosis in advanced disease stages, prognosis of patients with epithelial ovarian cancer (EOC) is poor. The quantification deregulated levels microRNAs could facilitate earlier and improve EOC. Seven (miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a miR-429) were quantified the serum 180 EOC 66 healthy women by TaqMan PCR microRNA assays. Median follow-up time was 21 months. effects miR-7 miR-429 on apoptosis, cell proliferation, migration invasion investigated two lines. Serum miR-25 (P=0.0001) miR-93 downregulated, whereas those (P=0.001) upregulated compared women. four discriminated from a sensitivity 93% specificity 92%. positively correlated CA125 values differed between FIGO I–II III–IV stages (P=0.001). MiR-429 an independent predictor overall survival (P=0.011). Overexpressed SKOV3 cells led suppression (P=0.037) Increased associated lymph node metastases (P=0.0001). resulted increased Additionally, (P=0.02). Our data indicate diagnostic potential miR-7, prognostic miR-429. This panel may be promising molecules targeted treatment