Rising incidence of bronchioloalveolar lung carcinoma and its unique clinicopathologic features.

摘要: Background. Bronchioloalveolar lung carcinoma (BAC) is a unique type of cancer with distinguishing pathologic, biologic, epidemiologic, demographic, and perhaps etiologic features. Methods. The authors investigated analyzed all the cases pathologically confirmed BAC seen at our institution in hope discovering new or confirming known features this disease. Results. When expressed as percentage total cancers were successive 5-year periods from 1955 to 1990, rose less than 5% 24.0% (P <0.001). Much increase occurred women, evidenced by male-to-female ratio that wavered around unity. mean age adenocarcinoma patients was 59.2 ± 11.5 years, compared 64.1 13.5 years for non-BAC <0.05). also contrasted other forms exhibiting relatively high incidence multifocality (25% versus 5%) There an association between histologic subtype pattern pulmonic involvement. mucinous more strongly associated diffuse involvement, sclerotic multifocal involvement Furthermore, exhibited 20% dedifferentiation into patterns poorly differentiated adenocarcinoma, feature subtypes <0.05). Conclusions. emergence prominent should stimulate basic laboratory case-control studies elucidate further natural history etiology disease. Cancer 1994; 73:1163-70.