The prognostic value of 18F-FDG PET/CT prior to liver transplantation for nonresectable colorectal liver metastases.

摘要: The main objective of this study was to evaluate the prognostic value volumetric and metabolic information derivied from F-18 fluorodeoxyglucose positron emission tomography (18F–FDG PET) in combination with computed (CT) prior liver transplantation (LT) patients nonresectable colorectal metastases (CLM). Due scarcity grafts, enabling selection candidates who will gain highest survival after LT is vital importance. 18F–FDG PET/CT a part preoperative protocol. Patients without evidence extrahepatic malignant disease on also fulfilled all other inclusion criteria underwent LT. examinations included SECA (secondary cancer) were retrospectively assessed. Maximum, mean peak standardized uptake values (SUVmax, SUVmean SUVpeak), tumor background (T/B) ratio, volume (MTV) total lesion glycolysis (TLG) measured calculated for metastases. Total MTV TLG each patient. Cut-off determined these parameters by using receiver operating characteristic (ROC) analysis dividing into two groups. One, three five-year overall (OS) free (DFS) over under cut-off compared Kaplan–Meier method log rank test. Twenty-three study. significantly correlated improved OS at five years (p = 0.027 0.026) DFS (p = 0.01). not related SUVmax, SUVmean, SUVpeak or T/B-ratio. 18F FDG CLM can potentially improve patient