Changes in CSF and plasma HIV-1 RNA and cognition after starting potent antiretroviral therapy

摘要: The authors assessed CSF and plasma HIV-1 RNA neuropsychological test performance (composite Z score [NPZ-4]) in 25 HIV-1-infected subjects 4 8 weeks after beginning potent antiretroviral therapy that included a protease inhibitor. In the 14 who entered study on no treatment, NPZ-4 improvement was associated with decline at both visits (p = 0.001 p 0.02), those treated zidovudine or indinavir had greater compared to other drugs 0.003 0.01).