Host Factors and Risk of Breast Cancer Recurrence: Genetic, Epigenetic and Biologic Factors and Breast Cancer Outcomes
作者： Christine B. Ambrosone , Chi-Chen Hong , Pamela J. Goodwin
DOI: 10.1007/978-3-319-16366-6_10
关键词:
摘要: Among women with breast cancer, there is wide variability in outcomes, both treatment-related toxicities and disease-free survival (DFS). Primary predictors of DFS are those related to the extent disease tumor characteristics, associated not only aggressiveness, but also responsiveness targeted therapies. Inherited germline variation may play a role cancer treatment have been studies targeting drug metabolism other candidate pathways as well genome-wide association (GWAS), which take more agnostic approach interrogate hundreds thousands single nucleotide polymorphisms (SNPs) determine that modify response treatment. While this field pharmacogenetics pharmacogenomics has held exciting promise for personalized medicine, results consistent, or effects profound, first hoped. An emerging prognosis epigenetics, regulates DNA expression can be influenced by numerous biologic processes environmental exposures. Although young, research likely holds understanding epigenetic mechanisms driving potential these factors through drugs approaches. Finally, circulating markers blood reflect some lifestyle relation particularly Vitamin D. In chapter, we highlight advances areas noted above, comment on impact interpretation from observational studies. We discuss future directions, avenues necessary move forward.
springer.com
sci-hub.se 参考文章(48)
Scott M. Langevin, Karl T. Kelsey, The fate is not always written in the genes: Epigenomics in epidemiologic studies Environmental and Molecular Mutagenesis. ,vol. 54, pp. 533- 541 ,(2013) , 10.1002/EM.21762
Scott M. Langevin, E. Andres Houseman, Brock C. Christensen, John K. Wiencke, Heather H Nelson, Margaret R. Karagas, Carmen J. Marsit, Karl T Kelsey, The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood Epigenetics. ,vol. 6, pp. 908- 919 ,(2011) , 10.4161/EPI.6.7.16431
Lisette Binkhorst, Ron H. J. Mathijssen, Myrthe P. P. van Herk-Sukel, Marjolein Bannink, Agnes Jager, Erik A. C. Wiemer, Teun van Gelder, Unjustified prescribing of CYP2D6 inhibiting SSRIs in women treated with tamoxifen Breast Cancer Research and Treatment. ,vol. 139, pp. 923- 929 ,(2013) , 10.1007/S10549-013-2585-Z
Matthew P. Goetz, Stacey K. Knox, Vera J. Suman, James M. Rae, Stephanie L. Safgren, Matthew M. Ames, Daniel W. Visscher, Carol Reynolds, Fergus J. Couch, Wilma L. Lingle, Richard M. Weinshilboum, Emily G. Barr Fritcher, Andrea M. Nibbe, Zeruesenay Desta, Anne Nguyen, David A. Flockhart, Edith A. Perez, James N. Ingle, The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen. Breast Cancer Research and Treatment. ,vol. 101, pp. 113- 121 ,(2007) , 10.1007/S10549-006-9428-0
Adriana Villaseñor, Rachel Ballard-Barbash, Anita Ambs, Leslie Bernstein, Kathy Baumgartner, Richard Baumgartner, Cornelia M. Ulrich, Bruce W. Hollis, Anne McTiernan, Marian L. Neuhouser, Associations of serum 25-hydroxyvitamin D with overall and breast cancer-specific mortality in a multiethnic cohort of breast cancer survivors. Cancer Causes & Control. ,vol. 24, pp. 759- 767 ,(2013) , 10.1007/S10552-013-0158-4
Christina Curtis, Sohrab P Shah, Suet-Feung Chin, Gulisa Turashvili, Oscar M Rueda, Mark J Dunning, Doug Speed, Andy G Lynch, Shamith Samarajiwa, Yinyin Yuan, Stefan Gräf, Gavin Ha, Gholamreza Haffari, Ali Bashashati, Roslin Russell, Steven McKinney, METABRIC Group Co-chairs Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 c, Writing committee Curtis† Christina 15 16 Shah Sohrab P. 17 18 Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 e, Steering committee Brenton James D. 15 16 Ellis Ian 19 Huntsman David 17 18 Pinder Sarah 20 Purushotham Arnie 20 Murphy Leigh 21 Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 j, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Chia Steven 18 Gelmon Karen 18 Huntsman David 17 18 McKinney Steven 17 18 Speers Caroline 18 Turashvili Gulisa 17 18 Watson Peter 17 18 21, University of Nottingham Ellis Ian 19 Blamey Roger 19 Green Andrew 19 Macmillan Douglas 19 Rakha Emad 19, King’s College London Purushotham Arnie 20 Gillett Cheryl 20 Grigoriadis Anita 20 Pinder Sarah 20 de Rinaldis Emanuele 20 Tutt Andy 20, Manitoba Institute of Cell Biology Murphy Leigh 21 Parisien Michelle 21 Troup Sandra 21, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Turashvili Gulisa 17 18 Bell Lynda 18 Chow Katie 18 Gale Nadia 18 Huntsman David 17 18 Kovalik Maria 18 Ng Ying 18 Prentice Leah 18, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Shah Sohrab P. 17 18 Bashashati Ali 17 Ha Gavin 17 Haffari Gholamreza 17 McKinney Steven 17 18, None, The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups Nature. ,vol. 486, pp. 346- 352 ,(2012) , 10.1038/NATURE10983
Janelle M. Hoskins, Lisa A. Carey, Howard L. McLeod, CYP2D6 and tamoxifen: DNA matters in breast cancer Nature Reviews Cancer. ,vol. 9, pp. 576- 586 ,(2009) , 10.1038/NRC2683
Vardhman K. Rakyan, Thomas A. Down, David J. Balding, Stephan Beck, Epigenome-wide association studies for common human diseases Nature Reviews Genetics. ,vol. 12, pp. 529- 541 ,(2011) , 10.1038/NRG3000
Wendell W. Weber, Sanford N. Cohen, The mechanism of isoniazid acetylation by human N-acetyltransferase Biochimica et Biophysica Acta. ,vol. 151, pp. 276- 278 ,(1968) , 10.1016/0005-2744(68)90184-8
Sophia Harlid, Zongli Xu, Vijayalakshmi Panduri, Dale P. Sandler, Jack A. Taylor, CpG Sites Associated with Cigarette Smoking: Analysis of Epigenome-Wide Data from the Sister Study Environmental Health Perspectives. ,vol. 122, pp. 673- 678 ,(2014) , 10.1289/EHP.1307480