Acute Oral or Dermal and Repeated Dose 90-Day Oral Toxicity of Tetrasodium Pyrophosphate in Spraque Dawley (SD) Rats.

摘要: OBJECTIVES Tetrasodium pyrophosphate (TSP) is used in processed meat products, as an emulsifier cheese, and a color preservative soybean paste. However, little known about its toxicity. This study was conducted to investigate the potential acute repeated dose toxicity of TSP Spraque Dawley (SD) rats. METHODS In study, animals were administered with oral or dermal doses 2,000 mg/kg TSP. 0, 250, 500, 1,000 by gavage five times week for 90 days. RESULTS studies, no dead abnormal necropsy findings found control treated group. there significant changes body weight treatment group, food consumption, urinalysis, hematology any With regards serum biochemistry, levels total protein, albumin, A/G ratio, triglyceride, calcium inorganic phosphate altered at 500 mg/kg. observed 250 histopathological findings, cortical tubular basophilia kidney increased mg/kg, but not No other organs CONCLUSIONS Based on results, unclassified according Globally Harmonization System, LD(50) value over The effect level (NOEL) adverse (NOAEL) /day respectively target organ appears be kidney.