Overview of Autophagy and Cardiometabolic Syndrome

摘要: The term cardiometabolic syndrome (CMS) refers to a constellation of cardiac metabolic and cardiovascular disease (CVD) risk factors including overweight/obesity, insulin resistance/hyperinsulinemia, hypertension, dyslipidemia, microalbuminuria. Obesity is central component the CMS that driven by consumption high fat/refined carbohydrate diet sedentary lifestyle. Persons with have an increased for development type 2 diabetes mellitus, CVD, chronic kidney disease. This related endothelial dysfunction, stiffness, impaired vascular diastolic relaxation, A pivotal systemic tissue resistance one important link between progression autophagy. Autophagy essential effective maintenance intracellular homeostasis quality control. However, this pathway dysregulated in characterized either inefficient autophagy or exaggerated/maladaptive resistance. Both signaling are altered through interactions excess dietary nutrients inappropriate activation renin-angiotensin-aldosterone system inflammation. overview addresses new insights into interaction abnormal genesis CMS, as well potential strategies drug targeting lifestyle interventions prevent and/or correct maladaptive improve sensitivity.