Effects of high-dose aprotinin on blood loss, platelet function, fibrinolysis, complement, and renal function after cardiopulmonary bypass.
作者： Barbara Blauhut , Christian Gross , Stan Necek , Jan Eva Doran , Peter Späth
DOI: 10.1016/S0022-5223(19)36611-5
关键词:
摘要: The use of aprotinin to reduce blood loss after cardiopulmonary bypass is under debate. Concern has been raised about the renal effects aprotinin. We administered a mean dose 4.2 × 106 kallikrein-inhibiting units 13 patients with coronary disease undergoing for 74 ± 5 minutes (mean standard error mean); comparable having served as control subjects, and all were studied postoperatively 24 hours. Aprotinin reduced postoperative by 50% (p = 0.0082). Two who received needed one red cell unit each versus total 18 in eight 0.0096). Blood pressure, hemoglobin value serum protein concentration higher operation group
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