Comparison of the effects of aprotinin and tranexamic acid on blood loss and related variables after cardiopulmonary bypass
作者： Barbara Blauhut , Wolfgang Harringer , Peter Bettelheim , Jan Eva Doran , Peter Späth
DOI: 10.1016/S0022-5223(12)70192-7
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摘要: Aprotinin reduces blood loss after cardiopulmonary bypass, but may sensitize recipients and is expensive. Tranexamic acid, a synthetic antifibrinolytic, has less disadvantages, opinions differ regarding its efficacy. We studied three groups of patients undergoing bypass for coronary disease: aprotinin (total dose 4.2 × 106 kallikrein inhibiting units, n =14), tranexamic acid 20 mg/kg body weight, =15), nonmedicated controls (n =14) during 24 hours bypass. Compared with controls, reduced loss, the number requiring transfusions, mean transfused red cell units (all p
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sci-hub.se 参考文章(60)
P. Zilla, R. Fasol, P. Groscurth, W. Klepetko, H. Reichenspurner, E. Wolner, Blood platelets in cardiopulmonary bypass operations. Recovery occurs after initial stimulation, rather than continual activation. The Journal of Thoracic and Cardiovascular Surgery. ,vol. 97, pp. 379- 388 ,(1989) , 10.1016/S0022-5223(19)34575-1
Barbara Blauhut, Christian Gross, Stan Necek, Jan Eva Doran, Peter Späth, Per Lundsgaard-Hansen, Effects of high-dose aprotinin on blood loss, platelet function, fibrinolysis, complement, and renal function after cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery. ,vol. 101, pp. 958- 967 ,(1991) , 10.1016/S0022-5223(19)36611-5
S J Brister, F A Ofosu, M R Buchanan, Thrombin generation during cardiac surgery: is heparin the ideal anticoagulant? Thrombosis and Haemostasis. ,vol. 70, pp. 259- 262 ,(1993) , 10.1055/S-0038-1649561
B Adelman, AD Michelson, J Greenberg, RI Handin, Proteolysis of platelet glycoprotein Ib by plasmin is facilitated by plasmin lysine-binding regions. Blood. ,vol. 68, pp. 1280- 1284 ,(1986) , 10.1182/BLOOD.V68.6.1280.1280
Michael D Boisclair, David A Lane, Helen Philippou, Sajila Sheikh, Beverley Hunt, Thrombin production, inactivation and expression during open heart surgery measured by assays for activation fragments including a new ELISA for prothrombin fragment F1 + 2. Thrombosis and Haemostasis. ,vol. 70, pp. 253- 258 ,(1993) , 10.1055/S-0038-1649480
Sterns Lp, Lillehei CW: Effect of epsilon aminocaproic acid upon blood loss following open-heart surgery: an analysis of 340 patients. Canadian Journal of Surgery. ,vol. 10, pp. 304- ,(1967)
KA Bauer, RD Rosenberg, Thrombin generation in acute promyelocytic leukemia. Blood. ,vol. 64, pp. 791- 796 ,(1984) , 10.1182/BLOOD.V64.4.791.791
Willem van Oeveren, Marcel P. Harder, Klaas J. Roozendaal, Leon Eijsman, Charles R.H. Wildevuur, Aprotinin protects platelets against the initial effect of cardiopulmonary bypass The Journal of Thoracic and Cardiovascular Surgery. ,vol. 99, pp. 788- 797 ,(1990) , 10.1016/S0022-5223(19)36893-X
J A Hoek, A Sturk, J W ten Cate, R J Lamping, F Berends, J J Borm, Laboratory and clinical evaluation of an assay of thrombin-antithrombin III complexes in plasma. Clinical Chemistry. ,vol. 34, pp. 2058- 2062 ,(1988) , 10.1093/CLINCHEM/34.10.2058
H. BÖHRER, A. BACH, F. FLEISCHER, J. LANG, Adverse haemodynamic effects of high-dose aprotinin in a paediatric cardiac surgical patient. Anaesthesia. ,vol. 45, pp. 853- 854 ,(1990) , 10.1111/J.1365-2044.1990.TB14571.X