Adult human dental pulp stem cells promote blood-brain barrier permeability through vascular endothelial growth factor-a expression.

摘要: Stem cell therapy is a promising new treatment option for stroke. Intravascular administration of stem cells valid approach as have been shown to transmigrate the blood-brain barrier. The mechanism that causes this effect has not yet elucidated. We hypothesized would mediate localized discontinuities in barrier, which allow passage into brain parenchyma. Here, we demonstrate adult human dental pulp express soluble factor increases permeability across an in vitro model This was be result vascular endothelial growth factor-a. could amplified by exposing stromal-derived 1, stimulates factor-a expression. These findings support use