VEGF-Mediated Effects on Brain Microvascular Endothelial Tight Junctions and Transmigration of Breast Cancer Cells Across the Blood-Brain Barrier

摘要: Breast cancer spreads to the bones, lungs, brain and liver. While mechanisms of breast metastasis bones lungs have been studied characterized, there is little information about molecular basis for brain. The disruption blood barrier (BBB) by metastases triple-negative basal-type cancers, but not Her2/neu positive cancer, was reported recently. To metastasize brain, cells must attach microvascular endothelial (BMECs) invade BBB. Structurally, BBB a comprised mainly BMECs. function maintained tight junctions protein complexes (TJs) between adjacent BMECs which zonula occudens-1 -2 (ZO-1 -2), occludin, claudins, junctional adhesion molecules, actin cingulin. Very known extravasation across their effects on TJs expression as well interactions with