作者: M.P. Morelli , M.J. Overman , A. Dasari , S.M.A. Kazmi , T. Mazard
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摘要: Introduction KRAS and EGFR ectodomain-acquired mutations in patients with metastatic colorectal cancer (mCRC) have been correlated acquired resistance to anti-EGFR monoclonal antibodies (mAbs). We investigated the frequency, co-occurrence, distribution of KRAS mCRC refractory mAbs using circulating tumor DNA (ctDNA).