The S492R EGFR ectodomain mutation is never detected in KRAS wild-type colorectal carcinoma before exposure to EGFR monoclonal antibodies.

作者: Claudia Esposito , Anna Maria Rachiglio , Maria Libera La Porta , Alessandra Sacco , Cristin Roma

DOI: 10.4161/CBT.26340

关键词: Colorectal cancerPanitumumabCetuximabMutantMonoclonal antibodyKRASMutationMolecular biologyEpidermal growth factor receptorMedicineCancer research

摘要: … , KRAS mutations have also been detected, at the time of tumor progression, in tumors from KRAS-… Conversely, ErbB-2 gene amplification has been detected in approximately 3% KRAS …

参考文章(22)
J Souglakos, J Philips, R Wang, S Marwah, M Silver, M Tzardi, J Silver, S Ogino, S Hooshmand, E Kwak, E Freed, J A Meyerhardt, Z Saridaki, V Georgoulias, D Finkelstein, C S Fuchs, M H Kulke, R A Shivdasani, Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. British Journal of Cancer. ,vol. 101, pp. 465- 472 ,(2009) , 10.1038/SJ.BJC.6605164
Andrea Bertotti, Giorgia Migliardi, Francesco Galimi, Francesco Sassi, Davide Torti, Claudio Isella, Davide Corà, Federica Di Nicolantonio, Michela Buscarino, Consalvo Petti, Dario Ribero, Nadia Russolillo, Andrea Muratore, Paolo Massucco, Alberto Pisacane, Luca Molinaro, Emanuele Valtorta, Andrea Sartore-Bianchi, Mauro Risio, Lorenzo Capussotti, Marcello Gambacorta, Salvatore Siena, Enzo Medico, Anna Sapino, Silvia Marsoni, Paolo M Comoglio, Alberto Bardelli, Livio Trusolino, None, A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. Cancer Discovery. ,vol. 1, pp. 508- 523 ,(2011) , 10.1158/2159-8290.CD-11-0109
Clara Montagut, Alba Dalmases, Beatriz Bellosillo, Marta Crespo, Silvia Pairet, Mar Iglesias, Marta Salido, Manuel Gallen, Scot Marsters, Siao Ping Tsai, André Minoche, Somasekar Seshagiri, Sergi Serrano, Heinz Himmelbauer, Joaquim Bellmunt, Ana Rovira, Jeff Settleman, Francesc Bosch, Joan Albanell, Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer Nature Medicine. ,vol. 18, pp. 221- 223 ,(2012) , 10.1038/NM.2609
Alberto Bardelli, Simona Corso, Andrea Bertotti, Sebastijan Hobor, Emanuele Valtorta, Giulia Siravegna, Andrea Sartore-Bianchi, Elisa Scala, Andrea Cassingena, Davide Zecchin, Maria Apicella, Giorgia Migliardi, Francesco Galimi, Calogero Lauricella, Carlo Zanon, Timothy Perera, Silvio Veronese, Giorgio Corti, Alessio Amatu, Marcello Gambacorta, Luis A. Diaz, Mark Sausen, Victor E. Velculescu, Paolo Comoglio, Livio Trusolino, Federica Di Nicolantonio, Silvia Giordano, Salvatore Siena, Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer Cancer Discovery. ,vol. 3, pp. 658- 673 ,(2013) , 10.1158/2159-8290.CD-12-0558
Nicola Normanno, Antonella De Luca, Caterina Bianco, Luigi Strizzi, Mario Mancino, Monica R. Maiello, Adele Carotenuto, Gianfranco De Feo, Francesco Caponigro, David S. Salomon, Epidermal growth factor receptor (EGFR) signaling in cancer Gene. ,vol. 366, pp. 2- 16 ,(2006) , 10.1016/J.GENE.2005.10.018
Nicola Normanno, Sabine Tejpar, Floriana Morgillo, Antonella De Luca, Eric Van Cutsem, Fortunato Ciardiello, Implications for KRAS status and EGFR-targeted therapies in metastatic CRC Nature Reviews Clinical Oncology. ,vol. 6, pp. 519- 527 ,(2009) , 10.1038/NRCLINONC.2009.111
K. Yonesaka, K. Zejnullahu, I. Okamoto, T. Satoh, F. Cappuzzo, J. Souglakos, D. Ercan, A. Rogers, M. Roncalli, M. Takeda, Y. Fujisaka, J. Philips, T. Shimizu, O. Maenishi, Y. Cho, J. Sun, A. Destro, K. Taira, K. Takeda, T. Okabe, J. Swanson, H. Itoh, M. Takada, E. Lifshits, K. Okuno, J. A. Engelman, R. A. Shivdasani, K. Nishio, M. Fukuoka, M. Varella-Garcia, K. Nakagawa, P. A. Janne, Activation of ERBB2 Signaling Causes Resistance to the EGFR-Directed Therapeutic Antibody Cetuximab Science Translational Medicine. ,vol. 3, ,(2011) , 10.1126/SCITRANSLMED.3002442
Sandra Misale, Rona Yaeger, Sebastijan Hobor, Elisa Scala, Manickam Janakiraman, David Liska, Emanuele Valtorta, Roberta Schiavo, Michela Buscarino, Giulia Siravegna, Katia Bencardino, Andrea Cercek, Chin-Tung Chen, Silvio Veronese, Carlo Zanon, Andrea Sartore-Bianchi, Marcello Gambacorta, Margherita Gallicchio, Efsevia Vakiani, Valentina Boscaro, Enzo Medico, Martin Weiser, Salvatore Siena, Federica Di Nicolantonio, David Solit, Alberto Bardelli, Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer Nature. ,vol. 486, pp. 532- 536 ,(2012) , 10.1038/NATURE11156
David Tougeron, Ulrich Cortes, Aurélie Ferru, Claire Villalva, Christine Silvain, Jean Marc Tourani, Pierre Levillain, Lucie Karayan-Tapon, Epidermal growth factor receptor (EGFR) and KRAS mutations during chemotherapy plus anti-EGFR monoclonal antibody treatment in metastatic colorectal cancer. Cancer Chemotherapy and Pharmacology. ,vol. 72, pp. 397- 403 ,(2013) , 10.1007/S00280-013-2211-0