Epidermal growth factor receptor (EGFR) and KRAS mutations during chemotherapy plus anti-EGFR monoclonal antibody treatment in metastatic colorectal cancer.
作者： David Tougeron , Ulrich Cortes , Aurélie Ferru , Claire Villalva , Christine Silvain
DOI: 10.1007/S00280-013-2211-0
关键词:
摘要: It is now well established that metastatic colorectal cancer patients without KRAS mutation (codon 12) benefit from treatment with an epidermal growth factor receptor monoclonal antibody (anti-EGFR mAb). Recently, EFGR and mutations have been shown to exist in who developed resistance anti-EGFR mAb. We analyzed KRAS, BRAF V600E EGFR S492R 37 post-anti-EGFR mAb tumor samples 23 treated chemotherapy plus No EGFRS492R was detected. A found after only one tumor. Our results suggest acquired do not constitute the main mechanism of combination chemotherapy.
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