Improving the delivery capacity of microparticle systems using blends of poly(DL-lactide co-glycolide) and poly(ethylene glycol)
作者： Ming-Kung Yeh , P.G. Jenkins , S.S. Davis , A.G.A. Coombes
DOI: 10.1016/0168-3659(95)00039-B
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摘要: Abstract The preparation of microparticles with an entrapped protein, ovalbumin (OVA), from blends poly (DL-lactide-co-glycolide) (PLG) and (ethylene glycol) (PEG) using a water-in oil-in oil (w/o/o) emulsion / solvent extraction technique is described. Significant increases in protein loading levels to over 50% (w/w) have been achieved larger than 10 μm mean diameter 25% small 2 microparticles. Linear release profiles are exhibited by certain blend formulations vitro 30 days. w/o/o formulation approach combination PLG/PEG shows potential for improving vaccine the delivery hydrophilic drugs, therapeutic proteins peptides.
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