Why Do Mice Overeat High-Fat Diets? How High-Fat Diet Alters the Regulation of Daily Caloric Intake in Mice.

摘要: Objective Ad libitum high-fat diets (HFDs) spontaneously increase caloric intake in rodents, which correlates positively with weight gain. However, it remains unclear why rodents overeat HFDs. This paper investigated how changing the proportion of diet that came from HFDs might alter daily mice. Methods Mice were given 25%, 50%, or 90% their need an HFD, along ad access to a low-fat rodent chow diet. Food was measured determine these HFD supplements impacted total intake. Follow-up experiments addressed timing feeding. Results did not body weight. In follow-up experiment, mice consumed approximately 50% 30 minutes during light cycle, time when do normally consume food. Conclusions An disrupt regulation intake, even up calories HFD. increased provided and readily by outside normal feeding cycle. appear induce overconsumption beyond mechanisms regulate