Hepatic Transcriptome Analysis of Hepatitis C Virus Infection in Chimpanzees Defines Unique Gene Expression Patterns Associated with Viral Clearance

摘要: Hepatitis C virus infection leads to a high rate of chronicity. Mechanisms viral clearance and persistence are still poorly understood. In this study, hepatic gene expression analysis was performed identify any molecular signature associated with the outcome hepatitis (HCV) in chimpanzees. Acutely HCV-infected chimpanzees self-limited or progression chronicity were studied. Interferon stimulated genes induced irrespective infection. Early induction set cell proliferation immune activation subsequent clearance. Specifically, two genes: interleukin binding factor 3 (ILF3) cytotoxic granule-associated RNA protein (TIA1), robust T-cell response, highly early Up-regulation CD8+ T response evident only during phase acute The these may represent an initial cellular injury that successfully translates “danger signal” leading adaptive immunity control This primary difference between chronic infections supports concept successful HCV-specific is critical HCV