Genetic variability of CYP2B6 polymorphisms in four southern Chinese populations.
作者： Bing-Ying Xu , Li-Ping Guo , Shui-Shan Lee , Qing-Ming Dong , Yi Tan
关键词:
摘要: AIM: To investigate the genotype and allelic frequencies of Cytochrome P450 2B6 polymorphisms in four southern Chinese populations. METHODS: DNA was obtained from blood samples Han Hong Kong three minority groups, Wa, Bulang Lahu Yunnan China. Genotyping performed using real-time PCR confirmed by direct sequencing. RESULTS: A total 507 subjects China were studied. Results showed there is a high prevalence 516G > T (34.5%) ethnic compared to literature reports on other Asian populations Caucasians. The frequency 516TT higher majority (23.1%) than groups (i.e., 7.4%, 9.1% 15.8%) China. CONCLUSION: This first study document spectrum CYP2B6 variants genotypes population. allele associated with defective metabolism efavirenz (EFV), which therefore may predispose drug toxicity. Treatment regimens for human immunodeficiency virus (HIV) heroin addiction need be optimized different because marked variability key metabolizing enzyme.
sci-hub.se 参考文章(15)
Heather J Ribaudo, Catia Marzolini, Todd Hulgan, David B Clifford, Richard B Kim, Edward P Acosta, Roy M Gulick, David W Haas, Camlin Tierney, Grant R Wilkinson, Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. AIDS. ,vol. 18, pp. 2391- 2400 ,(2004)
Thomas Lang, Kathrin Klein, Joachim Fischer, Andreas Nussler, Peter Neuhaus, Ute Hofmann, Michel Eichelbaum, Matthias Schwab, Ulrich Zanger, Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver. Pharmacogenetics. ,vol. 11, pp. 399- 415 ,(2001) , 10.1097/00008571-200107000-00004
Thomas Lang, Tanja Saussele, Eduardo Barbosa-Sicard, Wolf-Hagen Schunck, Michel Eichelbaum, Matthias Schwab, Ulrich M. Zanger, Kathrin Klein, Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz. Pharmacogenetics and Genomics. ,vol. 15, pp. 861- 873 ,(2005) , 10.1097/01213011-200512000-00004
Masahiro Hiratsuka, Yoh Takekuma, Naomi Endo, Kaori Narahara, Samar Hamdy, Yukinaga Kishikawa, Masaki Matsuura, Yasuyuki Agatsuma, Tomoko Inoue, Michinao Mizugaki, Allele and genotype frequencies of CYP2B6 and CYP3A5 in the Japanese population European Journal of Clinical Pharmacology. ,vol. 58, pp. 417- 421 ,(2002) , 10.1007/S00228-002-0499-5
Su Guan, Min Huang, Eli Chan, Xiao Chen, Wei Duan, Shu-Feng Zhou, Genetic polymorphisms of cytochrome P450 2B6 gene in Han Chinese European Journal of Pharmaceutical Sciences. ,vol. 29, pp. 14- 21 ,(2006) , 10.1016/J.EJPS.2006.04.004
S CRETTOL, J DEGLON, J BESSON, M CROQUETTEKROKKAR, I GOTHUEY, R HAMMIG, M MONNAT, H HUTTEMANN, P BAUMANN, C EAP, Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment Clinical Pharmacology & Therapeutics. ,vol. 78, pp. 593- 604 ,(2005) , 10.1016/J.CLPT.2005.08.011
Kiyoto Tsuchiya, Hiroyuki Gatanaga, Natsuo Tachikawa, Katsuji Teruya, Yoshimi Kikuchi, Munehiro Yoshino, Takeshi Kuwahara, Takuma Shirasaka, Satoshi Kimura, Shinichi Oka, Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens. Biochemical and Biophysical Research Communications. ,vol. 319, pp. 1322- 1326 ,(2004) , 10.1016/J.BBRC.2004.05.116
S. Rodriguez-Novoa, P. Barreiro, A. Rendon, I. Jimenez-Nacher, J. Gonzalez-Lahoz, V. Soriano, Influence of 516G>T Polymorphisms at the Gene Encoding the CYP450-2B6 Isoenzyme on Efavirenz Plasma Concentrations in HIV-Infected Subjects Clinical Infectious Diseases. ,vol. 40, pp. 1358- 1361 ,(2005) , 10.1086/429327
Noritaka Ariyoshi, Masafumi Miyazaki, Kenji Toide, Yu-ichi Sawamura, Tetsuya Kamataki, A Single Nucleotide Polymorphism of CYP2B6 Found in Japanese Enhances Catalytic Activity by Autoactivation Biochemical and Biophysical Research Communications. ,vol. 281, pp. 1256- 1260 ,(2001) , 10.1006/BBRC.2001.4524
Julia Kirchheiner, Christian Klein, Ingolf Meineke, Johanna Sasse, Ulrich M Zanger, Thomas E M??rdter, Ivar Roots, J??rgen Brockm??ller, Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6. Pharmacogenetics. ,vol. 13, pp. 619- 626 ,(2003) , 10.1097/00008571-200310000-00005