Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens.
作者： Kiyoto Tsuchiya , Hiroyuki Gatanaga , Natsuo Tachikawa , Katsuji Teruya , Yoshimi Kikuchi
DOI: 10.1016/J.BBRC.2004.05.116
关键词:
摘要: Efavirenz (EFV) is metabolized by cytochrome P450 2B6 (CYP2B6) in the liver. We analyzed genotypes of CYP2B6 and their contribution to plasma EFV concentrations 35 EFV-treated patients International Medical Center Japan. The mean concentration with *6/*6 (Q172H K262R) (25.4+/-7.5 microM, +/-SD, n = 2) was significantly higher than that *6 heterozygote (9.9+/-3.3 10) or without alleles (8.0+/-2.6 23) (p < 0.0001). To confirm our result, we further nine (three high arbitrarily selected six normal concentrations) treated Osaka National Hospital, it resulted only three were holder. dose could be decreased those harboring genotype reduce toxicity compromising potency, representing first step Tailor-Made therapy HIV-1 infection.
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